Everything You Need to Know About Dihydromyricetin

In addition to being referred to as Ampelopsin or DHM, dihydromyricetin powder (CAS No. 27200-12-0) is a bioactive flavanonol that is isolated from Ampelopsis grossedentata, which is also known as Vine Tea. It has achieved substantial commercial momentum across a variety of industries, including nutraceuticals, functional drinks, sports recovery, and nutricosmetics. It is a flavonoid that is naturally generated and bears the molecular formula C₁₅H₁₂O₈, as its name. The fact that it has been shown to have antioxidant properties, that it is effective in supporting the liver, and that it has a clean label profile makes it one of the most sought-after botanical ingredients in the B2B supplement market today. All of the information that procurement teams really need to know is included in this handbook.

What Is Dihydromyricetin? A Scientific and Market Overview

Origin and Chemical Identity

In the majority of cases, the 3,5,7,3′,4′,5′-hexahydroxy-2,3-dihydroflavonol known as DHM was discovered in Ampelopsis grossedentata, a thorny plant that is found in high quantities in southern China. The colour of this powder may vary from off-white to white, and it is classified as a fine, crystalline powder. It melts at temperatures between 245 and 246 degrees Celsius. Under normal circumstances, it maintains its solid state even when subjected to high temperatures, and it dissolves rapidly in both hot water and ethanol, both of which are essential characteristics for formulation. As a result of the fact that HPLC claims it is 98% pure, it consistently satisfies the global criteria for food additives.

Why the Market Is Paying Attention

The demand for vitamins derived from plants has increased at a rapid pace all across the globe. One of the reasons why DHM is unique is that it operates in two distinct biological routes. In the first place, it eliminates reactive oxygen species, also known as free radicals. Additionally, it has the ability to accelerate the activities of the enzymes known as Alcohol Dehydrogenase (ADH) and Acetaldehyde Dehydrogenase (ALDH). This facilitates the natural process that the body goes through to break down alcohol. DHM is the primary component of a wide variety of Products, including tablets that alleviate hangovers, mixtures that are beneficial to the liver, sports recovery powders, and even beauty supplements that are high in antioxidants. All of these categories of products are seeing growth in North American marketplaces that is more than ten percent.

Benefits and Safety Considerations of Dihydromyricetin Powder

Documented Functional Efficacy

Dihydromyricetin powder is the subject of more and more peer-reviewed research. Its three main jobs are to protect the liver, fight free radicals, and fight inflammation. The study by Shen et al. in the 2012 Journal of Neuroscience showed that DHM can help lessen the changes in behavior that come from drinking by working with GABA-A receptors. Also, research shows that DHM stops lipid peroxidation, which makes cells less stressed by oxidative stress. This is a very useful quality for both beauty products and health supplements.

When teams that buy things look for DHM, these are the main features that they always look for first:

• Hepatoprotective support: DHM accelerates ADH and ALDH enzyme activity, helping neutralize acetaldehyde buildup during alcohol metabolism, which makes it a natural fit for liver-support supplement formulas.
• Antioxidant potency: With strong radical scavenging capacity, DHM outperforms several synthetic antioxidants in DPPH assay benchmarks, offering formulation advantages for clean-label brands.
• Anti-inflammatory properties: DHM modulates inflammatory cytokine pathways, making it relevant for recovery-oriented sports nutrition products and functional wellness blends.
• Beauty and skin relevance: Its plant-derived antioxidant profile aligns with nutricosmetic formulas targeting skin oxidative stress—a priority for "inside-out beauty" brands.

DHM is not a niche compound for these reasons; it is an ingredient that can be used in many places. There is no way for wellness, exercise, or beauty brands to change who they are at their core.

Safety and Dosage Guidance

Between 100 mg and 600 mg per serving has been shown to work well in both clinical studies and the real world. Keep DHM in a cool, dry place for up to 24 months. It stops working when it comes into contact with rust and UV light. You can store it in vacuum-sealed, double-layer plastic containers to do this.

Dihydromyricetin Compared: Making the Right Choice for Your Business

DHM vs. Alternative Antioxidants

Most of the time, when procurement managers look at plant antioxidants, they compare DHM to silymarin from milk thistle or NAC. Being able to protect liver cells from toxins is a good thing about silymarin, but it doesn't break down alcohol as quickly as DHM does. NAC helps make glutathione, but DHM has a direct link with GABA receptors that NAC does not. DHM is useful in a way that neither Silymarin nor NAC is, because it does something different. It's especially helpful for health products that have to do with booze.

Product Format Considerations

You can buy DHM in shops as a solid powder, a standardized extract, or finished goods that are wrapped in a capsule. Businesses that buy from other businesses will find that ≥98% HPLC-pure raw powder gives them the most formulation options and the best value for money when they buy in bulk. People who want OEM/ODM output can choose between capsule and tablet forms. Native DHM doesn't mix well with cold water, which drink makers should know. This problem can be fixed by using gamma-cyclodextrin inclusion complexes, which also make the drug more bioavailable when it is in liquid form.

How to Procure High-Quality DHM Powder: A B2B Buying Guide

Certifications and Testing Standards to Require

In the DHM market, papers that can be checked show how trustworthy a seller is. If you want to find a source of dihydromyricetin powder from a china DHM powder factory, you should stick to a strict plan. OAZVITA's DHM powder is approved by HACCP, ISO 22000, NSF, HALAL, the EU, and the USDA. It also comes with all the paperwork you need for a batch, such as a COA, MSDS, and TDS. This makes it simple to follow all the rules for bringing goods into Europe and North America.

When they buy something, skilled business-to-business buyers will not skimp on these things:

• HPLC purity verification: Require a Certificate of Analysis confirming ≥98% purity per batch. Purity inconsistency is the leading quality complaint in botanical extract procurement.
• Third-party lab testing: Independent verification eliminates supplier bias. Request C14 radiocarbon analysis if natural origin confirmation is critical for your label claims.
• Organic certification relevance: For clean-label brands or EU/US market distribution, USDA Organic or EU Organic certification is increasingly non-negotiable with retail buyers.
• MOQ and lead time alignment: OAZVITA offers a 1 kg MOQ with a 1–5 working day lead time, enabling new product testing without overcommitting capital.

A lot less risk is involved in buying when these factors are in line with your sourcing plan. This also protects the purity of the product from the raw material to the store.

Logistics and Supply Chain Reliability

It is possible for OAZVITA to ship by air, sea, DHL, FedEx, UPS, and airmail. More than 99% of packages arrive on time. Because of this, foreign distributors who are in charge of supply lines that go to many markets can better plan their production and start times.

Future Trends and Innovations in DHM Utilization

People want natural chemicals that can be tracked and have been proven by science, so the supplement market is still changing. DHM is doing well during this change. A new study is looking into how it can help keep your metabolism healthy and protect your brain. This means it can be used for more than just breaking down alcohol. It should be more useful in functional drinks and high-nutrition products if the formulation is improved. This includes water-soluble DHM derivatives and nano-encapsulated delivery systems.

Progress in regulations is also good for DHM. For regulators in the US, EU, and big Asian countries, it is easy to get approval because it comes from plants and has a history of being safe. For as long as B2B buyers work with sellers now, before demand really hits its peak, prices will stay the same, and quantities will keep coming.

Conclusion

Now, dihydromyricetin powder is not just a specialized extract. It is a common functional ingredient that has been shown to work in many types of products. Not only is it safe and allowed by regulators, but it also protects the liver and is an antioxidant. These traits make it a great addition to vitamin, sports nutrition, functional food, and beauty product lines. Choose a provider with all the right certifications, regular purity, and quick logistics if you work in procurement. It can mean the difference between a good product launch and a supply chain risk. There's a lot of proof that DHM should be an important part of your food plan.

FAQ

1. Is DHM powder natural or synthetic?

OAZVITA's dihydromyricetin powder is 100% naturally extracted from Ampelopsis grossedentata (Vine Tea). Buyers requiring documentation of natural origin should request a C14 radiocarbon analysis, which confirms the botanical source beyond any doubt.

2. What purity level should B2B buyers require?

A minimum of 98% purity verified by HPLC is the industry standard for premium formulations. Lower purity grades introduce variability in biological activity and can complicate label claims during regulatory review.

3. Can DHM be used in beverage formulations?

Native DHM has limited cold-water solubility. Gamma-cyclodextrin inclusion complexes or water-soluble DHM derivatives resolve this effectively and are compatible with clear beverage applications.

4. What is the recommended serving range?

Clinical and market data support 100 mg to 600 mg per serving, typically consumed before or after alcohol intake when used in liver-support contexts.

Source Premium Dihydromyricetin Powder from OAZVITA

Dihydromyricetin powder is made by a trustworthy business called OAZVITA. They sell it to supplement brands, functional food makers, sports nutrition companies, and private label buyers in North America and around the world. We have ≥98% HPLC-pure DHM powder (CAS No. 27200-12-0) that is certified by ISO 22000, HACCP, NSF, USDA Organic, and EU Organic. For free samples, you have to wait between 1 and 5 days and place an order for at least 1 kg. To get a sample or custom quote right away, please email our team at info@oazvita.com.

References

1. Shen, Y., et al. "Dihydromyricetin as a Novel Anti-Alcohol Intoxication Medication." Journal of Neuroscience, 2012.

2. Wang, Y., et al. "Hepatoprotective Effects of Dihydromyricetin Against Alcohol-Induced Liver Injury." Journal of Ethnopharmacology, 2016.

3. Chen, S., et al. "Antioxidant and Anti-Inflammatory Properties of Dihydromyricetin: A Review." Food Chemistry, 2015.

4. Hou, X., et al. "Dihydromyricetin Improves Glucose and Lipid Metabolism in Obese Subjects." Evidence-Based Complementary and Alternative Medicine, 2017.

5. Xie, C., et al. "Bioavailability Enhancement of Dihydromyricetin Using Cyclodextrin Inclusion Complexes." International Journal of Pharmaceutics, 2019.

6. Liang, J., et al. "DHM Reduces Cellular Oxidative Stress via Nrf2 Pathway Activation." Oxidative Medicine and Cellular Longevity, 2020.